KLF1 gene and borderline hemoglobin A2 in Saudi population
نویسندگان
چکیده
منابع مشابه
KLF1 gene and borderline hemoglobin A2 in Saudi population
Introduction Elevated HbA2 (hemoglobin A2) level is considered the most reliable hematological parameter for the detection of β-thalassemia carriers. However, some carriers are difficult to recognize because the level of HbA2 is not in the distinctive carrier range, i.e. 4.0-6.0%; instead, some carriers have HbA2 levels between normal and carrier levels, i.e. borderline HbA2 (HbA2 = 3.1-3.9%). ...
متن کاملKLF1 gene mutations cause borderline HbA(2).
Increased hemoglobin A(2) (HbA(2); ie, levels > 3.9%) is the most important feature of β-thalassemia carriers. However, it is not uncommon to find persons with borderline HbA(2) (levels, 3.3%-3.8%), who pose a relevant screening problem. Several genotypes have been associated with borderline HbA(2), but sometimes the reasons for this unusual phenotype are unknown. In this paper, we report, for ...
متن کاملSignificance of borderline hemoglobin A2 values in an Italian population with a high prevalence of beta-thalassemia.
We report a retrospective analysis carried out on 23,485 subjects submitted to a screening program from 2000 to 2006. Of these subjects, 3,934 had borderline HbA(2) values from 3.1 to 3.9%; 410 samples, analyzed previously using PCR methods and sequencing because all of these were partners of a carrier of classical beta-thalassemia, were selected for statistical analysis. Of 410 subjects, 94 (2...
متن کاملRED CELLS, IRON, AND ERYTHROPOIESIS KLF1 gene mutations cause borderline HbA2
Increased hemoglobin A2 (HbA2; ie, levels > 3.9%) is the most important feature of -thalassemia carriers. However, it is not uncommon to find persons with borderline HbA2 (levels, 3.3%-3.8%), who pose a relevant screening problem. Several genotypes have been associated with borderline HbA2, but sometimes the reasons for this unusual phenotype are unknown. In this paper, we report, for the first...
متن کاملGlycosylated hemoglobin A2 components.
Partially purified hemoglobin A2 has been examined for the existence of glycosylated components by isoelectric focusing and by acid agar gel electrophoresis. Bands analogous to the glycohemoglobin derivatives of hemoglobin A, hemoglobin-A1.a.b.c, were readily detected. Evidence that these minor bands are in fact glycohemoglobins was obtained by showing that 14C-glucose bound to hemoglobin A2 mo...
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ژورنال
عنوان ژورنال: Archives of Medical Science
سال: 2018
ISSN: 1734-1922
DOI: 10.5114/aoms.2018.72245